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The conclusions described here are limited by the small sample-size, and a self-selection bias caused by the fact that only those patients who perceived the most benefit from Modafinil during the original trial chose to continue the drug long term. The conclusions described here are limited by the small sample-size, and a self-selection bias caused by the fact that only those patients who perceived the most benefit from Modafinil during the original trial chose to continue the drug long term. Psychostimulants in moderate to severe affective disorder: a systematic review of randomized controlled trials. Psychostimulants in moderate to severe affective disorder: a systematic review of randomized controlled trials. When you inject, you can't throw it up or spit it out. When you inject, you can't throw it up or spit it out. 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