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One study showed that a small 500 mg dose of valacyclovir is as effective as a larger 800 mg dose of acyclovir in preventing recurrence of HSV eye disease Valacyclovir is superiorto acyclovir in the treatment of herpes zoster. Acyclovir for cold sores is because of its improved bioavailability, which allows a lower dose of the drug to be used in treatment. Valaciclovir provides a useful alternative to acyclovir with the advantage of a more convenient dosing regimen and the potential for improved compliance.. The main difference between acyclovir and valacyclovir is that acyclovir must be taken more frequently than valacyclovir and is therefore now usually preferred for outpatient treatment. Twice-daily valaciclovir proved as effective and well tolerated in the treatment of first-episode genital herpes as five-times-daily acyclovir. This additional structures is then cleaved off in the liver to acyclovir Valtrex (valacyclovir) is an antiviral medication and is a first choice treatment for herpes virus infections including cold sores, genital herpes, and shingles. "Prepackaged" drug: Valacyclovir is exactly the same as acyclovir, except there is an additional chemical structure stuck to it, that allows the drug to be easily absorbed in the digestive system. Can I buy valacyclovir over the counter? Studies show that a small 500 mg dose of valacyclovir is as effective as a larger 800 mg dose of acyclovir in treating HSV One of the main reasons people may choose valacyclovir vs. If you are paying out of pocket for these medications, you may discover that there is a steep pricing difference between the two. This additional structures is then cleaved off in the liver to acyclovir • Acyclovir is the active drug while valaciclovir is the pro-drug. Acyclovir may be taken orally in the form of:. • Valaciclovir is more bioavailable than acyclovir. • Acyclovir gets removed from the circulation in the first pass metabolism while valaciclovir gets converted into active form during the first pass metabolism. Valacyclovir undergoes liver metabolism as it goes through the liver, to enter the systemic circulation. However, you are more likely to follow your medication regimen if you only need to take medicine once or twice a day versus five times per day. It has a better bioavailability than acyclovir. On the other hand, acyclovir is available as an oral suspension and tablets that dissolve under the tongue.. After entering the body esterase enzymes convert it to acyclovir and Valine. • Side effects are more common in valacyclovir Official answer by Drugs. Read on for a comparison of the two drugs This study compared valacyclovir 1000 mg taken three times a day for seven days with acyclovir 800 mg taken five times a day for seven days. Valacyclovir has a higher oral bioavailability. Valacyclovir may be much more expensive than Acyclovir. Acyclovir and valacyclovir are equally effective. Zovirax is also used to treat Epstein-Barr virus (mononucleosis). This allows for a patient to dose Valacyclovir less frequently while still achieving adequate antiviral levels in the body to treat various viral infections. The company that makes valacyclovir (Glaxo) funded the study. While both medications significantly shorten the periods of acute pain, time to complete zoster rash crusting and resolution, valaciclovir significantly accelerate the resolution of herpes zoster-associated pain compared with acyclovir5. Valacyclovir Prescription only Acyclovir is an antiviral drug that treats infections caused by HSV-1, HSV-2, and varicella-zoster viruses such as chickenpox, genital herpes, and shingles. For most pharmacies, you will find a much higher cost per tablet for Valacyclovir than for Acyclovir. Com Valacyclovir (Valtrex) and acyclovir (Zovirax) are antiviral drugs that work by interfering with viral DNA replication. Side effects of Valtrex and Zovirax that are similar include headache, nausea, vomiting, diarrhea, and rash Valacyclovir is superiorto acyclovir in the treatment of herpes zoster. It is most effective when started within more Prescription only Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir in the body Valacyclovir has a longer duration of action than Acyclovir Valacyclovir has a longer duration of action in the body than Acyclovir. Prescription only Acyclovir (Zovirax) is an antiviral medication used for the treatment of herpes, shingles, and chickenpox Both should be started as early as possible after the symptoms appear to be more effective, ideally within 72 hours. Although both drugs target the same viruses, there are a few differences between them. Valacyclovir and Acyclovir dosing is different. It can also be used to treat chickenpox in children.

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